Circuits Of coGnitive Systems (BRAIN COGS)

BRAIN COGS is a multi-lab NIH-funded project with six labs at PNI and one at UC Davis. It aims to determine how the brain produces decisions based on working memory. We are using a coordinated effort across all our labs to observe, map, perturb, and model brain circuits with state-of-the-art technologies. Our goal is for this work to lead to a major advance in basic science, that will, in turn, provide critical clues to therapeutic approachesWorking memory, the capacity to temporarily hold multiple pieces of information in mind for manipulation, is central to almost all cognitive abilities. Many mental diseases, including Alzheimer’s, schizophrenia, dementia, bipolar depression, autism, and attention-deficit/hyperactivity disorder, involve working memory.

The effort will be led by Princeton researchers Carlos Brody, the Wilbur H. Gantz III ’59 Professor in Neuroscience and a professor of molecular biology; Jonathan Pillow, an associate professor of psychology and the Princeton Neuroscience Institute (PNI); Sebastian Seung, the Evnin Professor in Neuroscience and a professor of computer science; David Tank, the Henry L. Hillman Professor in Molecular Biology and co-director of PNI; Samuel Wang, a professor of molecular biology and PNI; Ilana Witten, an assistant professor of psychology and PNI, and Mark Goldman, a professor of neurobiology, Center for Neuroscience at UC Davis.

NIH BRAIN Initiative builds on early advances
BRAIN COGS website

International Brain Laboratory (IBL)

Princeton Neuroscience Institute researchers are collaborating with scientists from 19 other laboratories around the world to create the International Brain Laboratory (IBL).  

Two PNI labs, led by 
Jonathan Pillow and Ilana Witten, are joining forces with researchers from Europe and the United States to crack the code on how the brain makes choices, by studying the activity and interactions between individual neurons across its different areas.

IBL is experimental & theoretical neuroscientists collaborating to understand brainwide circuits for complex behavior, with the aim to understand how the brain makes choices, down to the cellular level.

► Virtual mega-laboratory will probe the brain’s deepest secrets

Intel Labs and PNI Project

PNI and Intel Labs are working together to break new ground in the study of the brain and read the human mind. Using a system that focuses on human mapping, Princeton neuroscientists and Intel software engineers have collaborated to develop new algorithms in order to achieve real-time brain scan processing. 

Princeton-Intel collaboration breaks new ground in studies of the brain
Mapping the Mind with Artificial Intelligence

Rutgers-Princeton Center for Computational Cognitive Neuropsychiatry

In a major collaborative initiative, the Rutgers-Princeton Center for Computational Cognitive Neuropsychiatry (CCNP) opened its doors in February of 2017. The Center aims to improve the diagnosis of mental disorders, better predict their progression and eventually aid in developing treatments. The studies conducted at the center will address disorders ranging from depression, anxiety, and schizophrenia to obsessive-compulsive disorder and substance abuse.

New Rutgers-Princeton Center uses computational models to understand psychiatric conditions