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TitleSleep Spindle Refractoriness Segregates Periods of Memory Reactivation.
Publication TypeJournal Article
Year of Publication2018
AuthorsAntony, JW, Piloto, L, Wang, M, Pacheco, P, Norman, KA, Paller, KA
JournalCurr Biol
Volume28
Issue11
Pagination1736-1743.e4
Date Published2018 Jun 04
ISSN1879-0445
Abstract

The stability of long-term memories is enhanced by reactivation during sleep. Correlative evidence has linked memory reactivation with thalamocortical sleep spindles, although their functional role is not fully understood. Our initial study replicated this correlation and also demonstrated a novel rhythmicity to spindles, such that a spindle is more likely to occur approximately 3-6 s following a prior spindle. We leveraged this rhythmicity to test the role of spindles in memory by using real-time spindle tracking to present cues within versus just after the presumptive refractory period; as predicted, cues presented just after the refractory period led to better memory. Our findings demonstrate a precise temporal link between sleep spindles and memory reactivation. Moreover, they reveal a previously undescribed neural mechanism whereby spindles may segment sleep into two distinct substates: prime opportunities for reactivation and gaps that segregate reactivation events.

DOI10.1016/j.cub.2018.04.020
Alternate JournalCurr. Biol.
PubMed ID29804809
PubMed Central IDPMC5992601
Grant ListF31 MH100958 / MH / NIMH NIH HHS / United States