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TitleAdult Neurogenesis, Glia, and the Extracellular Matrix.
Publication TypeJournal Article
Year of Publication2019
AuthorsCope, EC, Gould, E
JournalCell Stem Cell
Volume24
Issue5
Pagination690-705
Date Published2019 May 02
ISSN1875-9777
Abstract

In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive to experience and may participate in hippocampal functions, including learning and memory, anxiety and stress regulation, and social behavior. Increasing evidence emphasizes the importance of new neuron connectivity within hippocampal circuitry for understanding the impact of adult neurogenesis on brain function. In this Review, we discuss how the functional consequences of new neurons arise from the collective interactions of presynaptic and postsynaptic neurons, glial cells, and the extracellular matrix, which together form the "tetrapartite synapse."

DOI10.1016/j.stem.2019.03.023
Alternate JournalCell Stem Cell
PubMed ID31051133