• A concept-centric figure illustration depicts a metaphorical real-life version of the digital “museum” of cells that the researchers have built. In this project, all 396 retinal ganglion cells within a single patch of mouse retina have been reconstructed. The digital “museum” provides 3D interactive view of each cell’s anatomy along with its functional data. Image by Julia Kuhl.
  • Professor Seung and researchers present the Eyewire Museum

    Sebastian Seung, the Evnin Professor in Neuroscience and a professor of computer science and the Princeton Neuroscience Institute (PNI), is unveiling the Eyewire Museum, an interactive archive of neurons available to the general public and neuroscientists around the world, including the hundreds of researchers involved in the federal Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. In the paper Digital Museum of Retinal Ganglion Cells with Dense Anatomy and Physiology from the journal Cell, a new kind of digital resource is presented that encompasses almost 400 ganglion cells from a single patch of mouse retina.
     
    Professor Seung and fellow researchers have created and shared detailed maps of more than 1,000 neurons in an online resource which provides a 3D interactive view of each cell’s anatomy, as well as graphs of its visual responses. With the help of a quarter-million video game players called "Eyewirers" -- members of an online community of video game players -- hundreds of thousands of hours have painstakingly pieced these neural cells together using data from a mouse retina gathered in 2009 at the Max Planck Institute for Medical Research in Heidelberg. Acknowledgment is also given to KT Corporation, which helped mobilize Eyewirers in Korea and throughout the world in the "Countdown to Neuropia" campaign.
     
    By turning a time-intensive research problem into an interactive game and crowdsourcing, Seung has built an unprecedented data set of neurons, which he is now turning over to the public via the Eyewire Museum. This is part of an ongoing effort to create the brain’s “parts list” by understanding retinal cells. “Working with Eyewirers around the world, we’ve made a digital museum that shows off the intricate beauty of the retina’s neural circuits,” Seung said.
     
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    Explore the Eyewire Museum: museum.eyewire.org