Pavel Osten, Cold Spring Harbor Laboratory

M.D., Ph.D., Associate Professor
Cold Spring Harbor Laboratory
Research Profile

“Mapping the brain at cellular resolution: academic and drug recovery applications”
Supported by the Amy C. Kern and John M. Goldsmith ‘85 Fund for Neuroscience
Thursday, September 19, 2019 - 12:00pm to Friday, September 20, 2019 - 11:45am
A32 PNI Lecture Hall
Hosted by: 
Sebastian Seung
Princeton Neuroscience Institute
Neuroscience Seminar Series

The beginning of the 21st century has seen a great renaissance in light microscopy in neuroscience, with new instruments and brain clearing and staining methods capable of generating complete datasets for the mouse brain at up to a submicron brainwide resolution. Here I will review the main pros and cons of the different types of the microscopy instrumentation and methods, and I will also describe our computational pipeline and toolchain software called Headlight for reconstruction, anatomical registration and computational analyses of the whole brain datasets. Finally, I will give examples of scientific applications from my lab at CSHL in systematic atlasing of cell-type distribution and morphology as well as from a biotech start-up Certerra focused on commercializing these methods for CNS drug screening.