William Bialek
Theory and Computation
Theory and Computation

Professor of Physics and Associate Director, Lewis-Sigler Institute for Integrative Genomics

Associated Faculty

Areas of Research: Computational Neuroscience
wbialek@princeton.edu
PDF icon william-bialek-cv.pdf
609-258-5929
237 Carl C. Icahn Laboratory


Research Focus

Interested in the interface between physics and biology, broadly interpreted. A central theme in my research is an appreciation for how well things "work" in biological systems. It is, after all, some notion of functional behavior that distinguishes life from inanimate matter, and it is a challenge to quantify this functionality in a language that parallels our characterization of other physical systems. Strikingly, when we do this (and there are not so many cases where it has been done!), the performance of biological systems often approaches some limits set by basic physicalprinciples. While it is popular to view biological mechanisms as an historical record of evolutionary and developmental compromises, these observations on functional performance point toward a very different view of life as having selected a set of near optimal mechanisms for its most crucial tasks. Even if this view is wrong, it suggests a theoretical physicist's idealization; the construction of this idealization and the attempt to calibrate the performance of real biological systems against this ideal provides a productive route for the interaction of theory and experiment, and in several cases this effort has led to the discovery of new phenomena. The idea of performance near the physical limits crosses many levels of biological organization, from single molecules to cells to perception and learning in the brain, and I have tried to contribute to this whole range of problems.


Selected Publications

Last updated 14 October 2012

Links to pdf versions of the papers, as available. Users areresponsible for compliance with copyright restrictions.

References to the physics e-print archive http://arxiv.org are given where available. For preprints this is a primary reference; for other work there may be slight differences between the e-print and conventional print versions of the paper. Since almost all of my papers are now deposited on the archive before journal publication, more recent papers are ordered by the date of the archive submission.


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