Innovative gene-delivery method for treatment of brain diseases

Esteban Engel, a researcher in viral neuroengineering and head of the Princeton Neuroscience Institute viral core, postdoctoral research associate Carola Maturana, and their colleagues have created new gene promoters to improve the delivery of large genes and enable them to remain active for long duration of time in neurons. The team is developing these promoters for use in gene therapy, to replace or improve genes that are malfunctioning. These novel promoters may be useful for treating diseases of the brain that are known to have a genetic component, such as Parkinson's disease, Huntington’s disease and Alzheimer's disease.  The new approach was published in the journal Molecular Therapy: Methods & Clinical Development and has received an IP accelerator grant for further development.

Read more on the Princeton Innovation website.

Summary: 

PNI researchers have created new gene promoters to improve the delivery of large genes and enable them to remain active for long duration of time in neurons.