Helen Mayberg, Icahn School of Medicine at Mount Sinai

Helen Mayberg

Professor, Icahn School of Medicine at Mount Sinai
Neuroscience Seminar Series
Supported by the John A. ’72 and Raluca V. Allison Fund for Discourse in Neuroscience

Title: 
“Iterative Strategies to Refine and Optimize DBS for Depression”
Date/Time: 
Thursday, February 8, 2018 - 4:00pm
Location: 
A32 Princeton Neuroscience Institute
Hosted by: 
Yael Niv
Department: 
Princeton Neuroscience Institute
Category: 
Neuroscience Seminar Series
Summary: 
Deep Brain Stimulation (DBS) is an emerging treatment strategy for patients with intractable depression with selection of the subcallosal cingulate (SCC) as a stimulation target based principally on converging findings from resting-state PET studies of conventional antidepressant interventions. At present, surgical implantation of DBS electrodes relies on high resolution structural images to localize the SCC grey matter-white matter border followed by trial-and-error behavioral testing of chronic stimulation at individual contacts. Clinical response may however be optimized by more precise targeting along specific white matter tracts as evidenced by recent diffusion tensor imaging and tractography analyses of DBS responders and non-responders. Catalyzed by availability of next generation devices that allow ongoing recordings of local field potentials in the targeted circuit of interest, recent work now combines multimodal neuroimaging with real-time behavioral and electrophysiological measurements, providing a more precise method to identify the optimal target location and stimulation parameters for individual patients. Strategic integration of neuroengineering innovations and selective animal models offers potential complementary perspectives to fully delineate critical pathways and mechanisms mediating antidepressant effects of SCC DBS and inform on the pathophysiology of treatment resistant depression more generally.