Development of efficient brain imaging technologies combining a high resolution with a large field of depth is a key step for a better understanding of brain neurocircuits. Functional ultrasound imaging (fUSi) is an innovative modality based on microDoppler ultrasound that can record brain activity at good spatial resolution (up to 10µm pixel size) and in real-time. Such result is achieved by using both a high frequency (up to 30 MHz) and a high imaging frame rate (up to 20 kHz) to track hemodynamic variations in single microvessels with a field of depth of several centimeters (enough to cover a full rodent brain). The benefits of this modality include excellent safety record, portability, affordable price and ease of use in comparison with fMRI or PET. fUSi is a complementary tool to better understand brain pathologies as confirmed by our recent findings on neurovascular coupling impairment in specific brain regions in stroke, AD and migraine. Importantly, fUSi can be performed in freely moving animals during behavioral tasks. Our recent development of a miniaturized motorized transducer offers a new way to identify brain circuits at large scale during learning and memory. fUSi has been designed for translational imaging and is currently evaluated for intraoperative neurosurgery in humans to identify epileptic foci or during resection of tumors.
Posted Sep 09 2016
Advances in functional UltraSound (fUS) imaging of brain activity from rodents to human
Thursday, September 15, 2016 - 4:00pm