Barry Jacobs
Human Neuroscience
Human Neuroscience

Professor of Psychology and the Princeton Neuroscience Institute

Ph.D., UCLA, 1971


barryj@princeton.edu
PDF icon barry-jacobs-cv.pdf
609-258-4438
174 Neuroscience


Research Focus

Our central interest is in brain monoamine neurotransmitters and their role in physiology and behavior, and especially how these brain chemicals relate to stress and mental illness. In addition, we are interested in how basic biological factors, drugs, and stress affect the production of new brain cells in adult animals. We explore these questions through recording single unit activity in behaving animals, c-Fos expression in brain, and immunohistochemical labeling of proliferating brain cells. The following types of questions exemplify our research interests. How are various aspects of motor output, including those associated with fatigue, related to the activity of brain serotonergic neurons. We have found, for example, that the activity of various brain stem serotonergic neurons is related to repetitive, unlearned movements, such as locomotion, chewing, and respiration. We have also found that the activity of these neurons becomes suppressed as fatigue sets in, for example, during treadmill-induced locomotion. Using c-Fos expression, we are examining how different stressors activate a variety of brain stem neuronal groups, such as the raphe nuclei and the locus coeruleus. We are especially interested in examining any resulting long-term changes. Finally, we are studying how drugs such as marijuana affect the production of new brain cells in adult animals


Selected Publications

  • Veasey, S.C., Fornal, C.A., Metzler, C.W. and Jacobs, B.L. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. Journal of Neuroscience, 1995, 15, 5346-5359.
  • Jacobs, B.L. and Fornal, C.A. Activation of 5-HT neuronal activity during motor behavior. Seminars in Neuroscience, 1995, 7, 401-408.
  • Fornal, C.A., Metzler, C.W., Marrosu, F, Ribiero-do-Valle, L.E. and Jacobs, B.L. A subgroup of dorsal raphe serontonergic neurons in the cat is strongly activated during oral-buccal movements. Brain Research, 1996, 716, 123-133.
  • Rueter, L.E. and Jacobs, B.L. Changes in forebrain serotonin at the light-dark transition: correlation with behaviour. Neuroreport, 1996, 7, 1107-1111.
  • Rueter, L.E. and Jacobs, B.L. A microdialysis examination of serotonin release in the rat forebrain induced by behavioral/environmental manipulations. Brain Research, 1996, 739, 57-69.
  • Fornal, C.A., Metzler, C.W., Gallegos, R.A., Veasey, S.C., McCreary, A.C. and Jacobs, B.L. WAY-100635, a potent and selective 5-hyrdroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. Journal of Pharmacology and Experimental Therapeutics, 1996, 278, 752-762.
  • Mendlin, A., Martin, F.J., Rueter, L.E., and Jacobs, B.L. Neural release of serotonin in the cerebellum of behaving rats: An in vivo microdialysis study. J. Neurochem., 1996, 67, 617-622.
  • Marrosu, F., Fornal, C.A., Metzler, C.W. and Jacobs, B.L. 5-HT1A agonists induce hippocampal theta activity in freely moving cats: role of presynaptic 5-HT1A receptors. Brain Research, 1996, 739, 192-200.
  • Gardner, J.P., Fornal, C.A. and Jacobs, B.L. Effects of sleep dprivation on serotonergic neuronal activity in the dorsal raphe nucleus of the freely moving cat. Neuropsychopharmacology, 1997, 17, 72-81.
  • Jacobs, B.L. and Fornal, C.A. Physiology and pharmacology of brain serotonergic neurons. In: Handbook of Experimental Pharmacology: Serotoninergic neurons and 5-HT receptors in the CNS. H.G. Baumgarten and M. Gothert (eds.) Springer, 1997, 91-116.
  • Veasey, S.C., Fornal, C.A., Metzler, C.W. and Jacobs, B.L. Single-unit responses of serotonergic dorsal raphe neurons to specific motor challenges in freely moving cats. Neuroscience, 1997, 79, 161-169.
  • Horvitz, J.C. and Jacobs, B.L. Burst activity of ventral tegmental dopamine neurons is elicited by sensory stimuli in the awake cat. Brain Research, 1997, 759, 251-258.
  • Rueter, L.E., Fornal, C.A. and Jacobs, B.L. A critical review of 5-HT brain microdialysis and behavior. Reviews in Neuroscience, 1997, 8, 117-137.
  • Jacobs, B.L. and Fornal, C.A. Serotonin and motor activity. Current Opinion in Neurobiology, 1997, 7, 820-825.
  • Mendlin, A., Martin, F.J. and Jacobs, B.L. Involvement of dopamine D2 receptors in apomorphine-induced facilitation of forebrain serotonin output. European Journal of Pharmacology, 1998, 351, 291-298.
  • Bjorvatn, B., Fornal, C.A., Martín, F.J., Metzler, C.W., and Jacobs, B.L. The 5-HT1A receptor antagonist p-MPPI blocks 5-HT1A autoreceptors and increases dorsal raphe unit activity in awake cats. European Journal of Pharmacology, 1998, 356, 167-178.
  • Mendlin, A., Martin, F.J. and Jacobs, B.L. Dopaminergic input is required for increases in 5-HT output produced by behavioral activation: An in vivo microdialysis study in rat forebrain. Neuroscience, 1999, 93, 897-905.
  • Juckel, G., Mendlin, A. and Jacobs, B.L. Electrical stimulation of medial prefrontal cortex enhances forebrain serotonin output. Implications for electroconvulsive therapy and transcranial magnetic stimulation in depression. Neuropsychopharmacology, 1999, 21, 391-398.
  • Jacobs, B.L. and Fornal, C.A. Activity of serotonergic neurons in behaving animals. Neuropsychopharmacology, 1999, 21, 9S-15S. Fornal, C.A., Martin, F.J., Mendlin, A., Metzler, C.W., Bjorvatn, B. and Jacobs, B.L. Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity. European Journal of Pharmacology, 1999, 377, 187-191.
  • Fornal, C.A., Martin, F.J., Metzler, C.W. and Jacobs, B.L. Pindolol, a putative 5-hydroxytryptamine1A antagonist does not reverse the inhibitionof serotonergic neuronal activity induced by fluoxetine in awake cats: comparison to WAY-100635. Journal of Pharmacology and Experimental Therapeutics, 1999, 291, 220-228.
  • Fornal, C.A., Martin, F.J., Metzler, C.W. and Jacobs, B.L. Pindolol suppresses serotonergic neuronal activity and does not block the inhibition of serotonergic neurons produced by 8-hydroxy-2-(di-n-propylamino) tetralin in awake cats. Journal of Pharmacology and Experimental Therapeutics, 1999, 291, 229-238.
  • Jacobs, B. L. Hallucinogens. In: Encyclopedia of Psychology, A E. Kazdin (Ed.) Oxford University Press, 2000, Vol. 4, 57-58. Jacobs, B.L., van Praag, H. and Gage, F.H. Adult neurogenesis and psychiatry: a novel theory of depression. Molecular Psychiatry, 2000, 5, 262-269.
  • Bjorvatn, B., Fornal., C.A., Martin, F.J., Metzler, C.M. and Jacobs, B.L. Venlafaxine and its interaction with WAY 100635: effects on serotonergic unit activity and behavior in cats. European Journal of Pharmacology, 2000, 404, 121-132.
  • Jacobs, B.L. van Praag, H. and Gage, F.H. Depression and the birth and death of brain cells. American Scientist, 2000, 88, 340-345. Martin-Cora, F.J., Fornal, C.A., Metzler, C.W. and Jacobs, B.L. Single-unit responses of serotonergic medullary and pontine raphe neurons to environmental cooling in freely moving cats. Neuroscience, 2000, 98, 301-309.
  • Fornal, C. A., Metzler, C. W., Mirescu, C., Stein, S. K., and Jacobs, B. L. Effects standardized extracts of St. John’s Wort on the single-unit activity of serotonergic dorsal raphe neurons in awake cats: Comparisons with fluoexetine and sertraline.
  • Neuropsychopharmacology, 2001, 25, 858-870.
  • Fornal, C. A., Metzler, C. W. Mirescu, C. Stein, S. K. and Jacobs, B. L. Effects of standardized extracts of St. John’s wort on the single-unit activity of serotonergic dorsal raphe neurons in awake cats: comparison with fluoxetine and sertraline. Neuropsychopharmacology, 2001, 25, 858-870.
  • Jacobs, B. L. Adult brain neurogenesis and depression. Brain, Behavior, and Immunity, 2002, 16, 602-609.
  • Martín-Cora, F. J., Fornal, C. A., Metzler, C. W. and Jacobs, B. L. Insulin-induced hypoglycemia decreases single-unit activity of serotonergic medullary raphe neurons in freely moving cats: European Journal of Neuroscience, 2002, 16, 722-734.
  • Radley, J. J. and Jacobs, B. L. 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus, Brain Research, 2002, 955, 264-267.
  • Jacobs, B. L., Martín-Cora, F. J. and Fornal, C. A. Activity of medullary serotonergic neurons in freely moving animals. Brain Research Reviews, 2002, 40, 45-52.
  • Radley, J. J. and Jacobs, B. L. Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a serotonin-1A receptor dependent mechanism, Brain Research, (in press).